I use them fine with my left hand. There’s no reason to stay on home row if you’re doing a lot of copy and paste. Of course, if you’re doing that much copy and paste, using an extension that allows VIM shortcuts would be much faster.

If you don’t like BÉPO because you want familiar letter-based clipboard shortcuts, you’ve already made a better layout selection impossible. I learned to use the older clipboard shortcuts: ctrl+ins for copy, shift+ins for paste, and shift+del for cut. Those are still as universally supported.