Why not? :(

Done it plenty of times before using nixos on SBC’s, its a ram hog when rebuilding

Swap space could help install a slow Linux DE, if youre still inclined

So?

Using the right build platform you could design a single flag to enable automatic appimage building as well.

Just seems like a cleaner build environment to me, exactly what you’d want to gaurentee things remain distro agnostic

Sounds like flatpaks/appimages with extra steps

Includes all dependencies? ✔️

A single file? ✔️

Independent of host libraries? ✔️

Limited learning curve? ✔️

Not sure how appimages handle it internally, but with flatpaks you can even be storage efficient with layers, whereas 100s of static binaries could contain an awful lot of duplicates.